I recently read a book where the title was a play on words. It was a single word but spelled slightly different as if made up of two words. It did have meaning to the book and I can see why the author liked it.
When I thought about mentioning the book to someone I refrained. They would have asked for the name and I would have to go into a big long explanation about the different title. If I just used the real word the unique spelling would have made it hard to find. So I just didn't mention it. And in a business where the best advertisement is word of mouth that's a killer.
You may want to think about that if you are leaning towards naming you book something made up or with unique spellings. Will your reader be able to find you? And will people want to explain, or talk about the title?